Table 3.
Summary of ESFT cell lines studied.
| Cell line | ESFT type | EWS-FLI-1 type |
HLA-A2.1 | IFN-γ | Description | Ref |
|---|---|---|---|---|---|---|
| TC-71 | ES | 1 | ++ | +++ | Recurrent tumor of the humerus derived from a 22-year old male |
(38) |
| WE-68 | ES | 1 | +++ | Primary tumor derived from the fibula of a 19-year old female |
(39) | |
|
A673> (RMS1598) |
Unknown | 1 | ++ | +++ | Unknown subtype: Derived from the muscle of a 15-year old female. Initially believed to be a rhabdomyosarcoma. |
(40) |
| EWS502 | Unknown | 1 | + | +++ | Unknown subtype | (41) |
| Rh1 (EW8) | Unknown | 1 | +++ | Unknown subtype: Initially believed to be an alveolar rhabdomyosarcoma. |
(13) | |
| TC-32 | pPNET | 1 | +++ | Primary tumor derived from the pelvis of a 17-year old female |
(38 | |
| SK-PN-DW | pPNET | 1 | + | +++ | Primary tumor derived from the presacrum of a 17-year old male |
(42) |
| STA-ET.1 | pPNET | 1 | ++ | +++ | Recurrent tumor of the humerus derived from a 13-year old female |
(43) |
| TTC-547 | BPT | 1 | − | +++ | Primary tumor derived from the retroperitoneum of a 13-year old female |
(14) |
| TC-174 | BPT | 1 | +++ | Primary tumor originating in the soft tissue of the thigh of a 9-year old female |
(14) | |
| TC-83 | AT | 1 | +++ | Derived from the chest wall of a 13-year old female |
(44) | |
| RD-ES | ES | 2 | − | − | Derived from the humerus of a 19-year old male. |
(45) |
| SK-N-MC | pPNET/AT | 1 | − | − | Derived from the supraorbital metastasis of 14-year old female |
(46) |
| SK-ES-1 | pPNET | 2 | + | +++ | Isolated from an 18-year old male | (47) |
ES: Ewing’s Sarcoma, Unknown: Tumor type undefined, pPNET: peripheral Primitive NeuroEctodermal Tumor, AT: Askin’s Tumor, and BPT: Biphenotypic sarcoma. Percent HLA-A2.1 expression as determined by FACS: Not detected: (−), 1–40: (+), 41–89: (++), 90–100: (+++)). IFN-γ: HLA-A2.1 expression following 48 hours in the presence of 300U/ml rhIFN-γ.