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Dose normalized mean plasma concentration-time profiles of (A) dasatinib and (B) paclitaxel. The plasma concentrations for dasatinib (dasatinib alone (solid circles)) were lower after co-administration of paclitaxel (open circles) (A). Compared to paclitaxel alone treatment (solid circles and solid triangles), paclitaxel administered with dasatinib (open circles) showed comparable exposure to paclitaxel and 6-OH paclitaxel (combination with dasatinib (open triangles)) (B).
