. 2012 Oct;40(10):1883–1893. doi: 10.1124/dmd.111.043901

TABLE 1.

Pharmacokinetic parameters of genistein, G-7-G, G-4′-S, and G-7-S in WT and BCRP(−/−) mice after oral administration

Pharmacokinetic parameters in BCRP(−/−) mice were compared to WT mice at the same dose. Data are presented as means ± S.D.; n = 5.

	Strain	Dose	C_max	k_e	t_1/2	AUC_0–_t
		mg/kg	μM	h⁻¹	h	h · μM
Genistein	FVB	2	0.10 ± 0.05	N.A.	N.A.	0.36 ± 0.17
	BCRP(−/−)	2	0.23 ± 0.17	0.27 ± 0.20	3.8 ± 2.7	0.71 ± 0.24^*
	FVB	20	0.65 ± 0.22	N.A.	N.A.	6.05 ± 0.54
	BCRP(−/−)	20	3.35 ± 0.65^**	N.A.	N.A.	16.41 ± 4.23^*
G-7-G	WT	2		N.A.	N.A.	0.15^a
	BCRP(−/−)	2	0.30 ± 0.16	N.A.	N.A.	1.87 ± 0.68^*
	WT	20	1.07 ± 1.03	N.A.	N.A.	3.49 ± 2.58
	BCRP(−/−)	20	9.63 ± 5.65^*	0.16 ± 0.10	5.5 ± 3.3	56.71 ± 43.87^*
G-4′-G	WT	2		N.A.	N.A.	0.12^a
	BCRP(−/−)	2	0.11 ± 0.12	0.28 ± 0.23	3.7 ± 3.0	0.26 ± 0.17
	WT	20	0.52 ± 0.37	0.25 ± 0.25	6.5 ± 6.5	1.56 ± 0.79
	BCRP(−/−)	20	2.14 ± 1.44^*	0.15 ± 0.10	6.2 ± 3.3	15.19 ± 11.16^*
G-4′-S	WT	2	0.04 ± 0.03	0.17 ± 0.01	4.0 ± 0.3	0.13 ± 0.04
	BCRP(−/−)	2	0.14 ± 0.11	N.A.	N.A.	1.37 ± 1.17^*
	WT	20	0.25 ± 0.22	0.32 ± 0.19	2.7 ± 1.3	1.03 ± 0.64
	BCRP(−/−)	20	6.18 ± 4.14^*	0.30 ± 0.10	2.4 ± 0.7	26.78 ± 13.79^*
G-7-S	WT	2	0.08 ± 0.02	0.27 ± 0.07	2.7 ± 0.6	0.32 ± 0.05
	BCRP(−/−)	2	0.17 ± 0.05	0.21 ± 0.03	3.4 ± 0.5	1.13 ± 0.81^*
	WT	20	0.65 ± 0.56	0.21 ± 0.18	5.6 ± 4.5	2.49 ± 1.51
	BCRP(−/−)	20	4.39 ± 2.55^*	0.25 ± 0.09	2.9 ± 1.1	20.92 ± 8.86^**

N.A., not available because of poor fitting value (R² < 0.8) in the terminal phase.

p < 0.05.

^**

p < 0.01.

Estimated AUC_0–_t.