TABLE 2.

Pharmacokinetic parameters of genistein, G-7-G, G-4′-S, and G-7-S in WT and BCRP(−/−) mice after an intraperitoneal injection of 20 mg/kg

Pharmacokinetic parameters in Bcrp1(−/−) mice were compared to WT mice at the same dose. Data are presented as mean ± S.D.; n = 5.

	Strain	Cmax	ke	t1/2	AUC0–t
		μM	h−1	h	h · μM
Genistein	WT	2.68 ± 0.86	0.23 ± 0.09	4.8 ± 4.2	10.0 ± 2.30
	BCRP(−/−)	4.42 ± 1.04*	0.52 ± 0.33	2.8 ± 2.8	11.54 ± 5.57
G-7-G	WT	0.93 ± 0.38	N.A.	N.A.	3.26 ± 2.18
	BCRP(−/−)	4.28 ± 2.08*	0.55 ± 0.38	3.0 ± 3.0	10.84 ± 6.86*
G-4′-S	WT	0.64 ± 0.29	0.30 ± 0.30	4.2 ± 3.1	1.91 ± 1.16
	BCRP(−/−)	8.18 ± 5.07*	0.35 ± 0.22	3.1 ± 2.7	33.90 ± 31.78*
G-7-S	WT	1.73 ± 0.85	0.82 ± 0.53	1.1 ± 0.6	3.96 ± 3.41
	BCRP(−/−)	11.31 ± 6.63*	0.13 ± 0.03*	5.4 ± 1.2*	28.74 ± 24.13*

N.A., not available because of poor fitting value (R² < 0.8) in the terminal phase.

^* p < 0.05.

** p < 0.01.