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. 2012 Sep 4;31(19):3901–3917. doi: 10.1038/emboj.2012.248

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Copyright © 2012, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Wg from enteroblasts (EBs) is required for Myc-dependent ISC proliferation during regeneration. (A–H′) Wg staining (red) from midguts expressing the EB driver Su(H)GBE-gal4 gfp only (A–D′) or in combination with RNAi for wg (E–H′). Note the impairment in Wg upregulation in response to damage in midguts with wg knockdown in EBs. Panels (B, B′, D, D′, F, F′, H, H′) show high magnification views from the boxed areas in the left panels. Arrows point to Wg^+ve cells. (I) Wg levels represented as the average fluorescence intensity from three independent samples for each of the conditions and genotypes analysed. (J) Quantification of pH3^+ve cells in the indicated genotypes. Note that when driven with Su(H)-gal4, and in contrast to myc knockdown, midguts with wg knockdown failed to proliferate in response to damage (***P<0.0001 one-way ANOVA with Bonferroni’s multiple comparison test). Scale bars: 40 μm.