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Disappearance of HCV RNA and HCV NS3/4A inhibition with biliverdin, heme, or ZnPP. (A–C) HCV RNA was determined in total RNA extracted from replicon cells incubated with the indicated concentrations of tetrapyrrole for 48 h. Independent determinations of the inhibitory activity of each tetrapyrrole for recombinant HCV NS3/4A was determined by FRET analysis (Zhu et al., 2010a). Results are means ± SEM of six determinations per point. (With permission; Zhu et al., 2011.)
