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. 2012 Jul 18;32(10):1948–1958. doi: 10.1038/jcbfm.2012.100

Figure 2.

Figure 2

Ultrasound-induced localized delivery in rat brain of magnetic resonance imaging (MRI) contrast agents (CA) with different hydrodynamic diameters. Paramagnetic CA (Dotarem, P846 and P792) or ultrasmall superparamagnetic iron oxide (USPIO) CA (P904 and P03680) were injected in rats immediately after ultrasound-induced blood–brain barrier (BBB) disruption, and the signal intensities were measured within 5 minutes at the ultrasound focal point. T1w images of the paramagnetic CA (A–C) revealed a positive contrast, while T2w images of the USPIO revealed a negative contrast (D, E). Comparison of the signal enhancement in arbitrary units (a.u.) in the region of interest of ultrasound focal point (ROIspot, n°1) and that in the control contralateral region (ROIcontra, n°2) is given next to the scan corresponding to each CA (n=1 rat for each CA). The error bars correspond to the standard deviation observed within each ROI. Differences between the two regions were considered significant for P values <0.01 (*) using a Student's t-test. ROI, region of interest.