. 2012 Sep 10;3:351. doi: 10.3389/fphys.2012.00351

Table A2.

Calcium and buffer reaction-diffusion parameters.

Symbol	Definition	Value	Reference
Ca²⁺, Na⁺, AND BUFFER CONCENTRATIONS
[Ca²⁺]_o	Extracellular Ca²⁺ concentration	2000 μM	Sobie et al. (2008)
[Ca²⁺]_i0	Resting Ca²⁺ concentration	0.1 μM	Sobie et al. (2008)
[Na⁺]_o	Extracellular Na⁺ concentration	140 mM	Sobie et al. (2008)
[Na⁺]_i0	Resting Na⁺ concentration	10 mM	Sobie et al. (2008)
[TN]	Total troponin concentration	70 μM	Shannon et al. (2004)
[ATP]	Total free ATP concentration	260 μM	Cheng et al. (2010)
[CaM]	Total calmodulin concentration	24 μM	Shannon et al. (2004)
[Fluo]	Total Fluo-3 concentration	50 μM	Sobie et al. (2008)
DIFFUSION CONSTANTS (AT 22°C)
D_ca	Diffusion coefficient for Ca²⁺	0.39 μm² ms⁻¹	Cheng et al. (2010)
D_CaFluo	Diffusion coefficient for CaFluo	0.1 μm² ms⁻¹	Cheng et al. (2010)
D_CaATP	Diffusion coefficient for CaATP	0.168 μm² ms⁻¹	Cheng et al. (2010)
D_CaCam	Diffusion coefficient for CaCaM	0.025 μm² ms⁻¹	Cheng et al. (2010)
RATE COEFFICIENTS AND DISSOCIATION CONSTANTS (AT 22°C)
$k_{+}^{CaTN}$	Ca²⁺ on-rate constant for TN	0.04 μM⁻¹ ms⁻¹	Shannon et al. (2004)
$k_{+}^{CaTN}$	Ca²⁺ off-rate constant for TN	0.04 ms⁻¹	Shannon et al. (2004)
$k_{D}^{TN}$	Ca²⁺ dissociation constant for TN	1 μM	Shannon et al. (2004)
$k_{+}^{CaATP}$	Ca²⁺ on-rate constant for CaATP	0.225 μM⁻¹ ms⁻¹	Cheng et al. (2010)
$k_{-}^{CaATP}$	Ca²⁺ off-rate constant for CaATP	45 ms⁻¹	Cheng et al. (2010)
$k_{D}^{ATP}$	Ca²⁺ dissociation constant for ATP	200 μM	Cheng et al. (2010)
$k_{+}^{CaCaM}$	Ca²⁺ on-rate constant for Cal	0.125 μM⁻¹ ms⁻¹	Shannon et al. (2004)
$k_{-}^{CaCaM}$	Ca²⁺ off-rate constant for Cal	0.2975 ms⁻¹	Shannon et al. (2004)
$k_{D}^{CaM}$	Ca²⁺ dissociation constant for Cal	2.38 μM	Shannon et al. (2004)
$k_{+}^{CaFluo}$	Ca²⁺ on-rate constant for CaFluo	0.23 μM⁻¹ ms⁻¹	Cheng et al. (2010)
$k_{-}^{CaFluo}$	Ca²⁺ off-rate constant for CaFluo	0.17 ms⁻¹	Cheng et al. (2010)
$k_{D}^{Fluo}$	Ca²⁺ dissociation constant for Fluo	0.739 μM	Cheng et al. (2010)