FIGURE 1.

Parasite and host factors contribute to disease outcome in human L. braziliensis infection.Parasite polymorphisms are associated with clinical forms of the disease. The type of immune response developed by the host, determine whether parasite growth will be controlled or dissemination will occur. Detection of Leishmania in blood from SC individuals has not been achieved. Exaggerated pro-inflammatory immune response leads to tissue damage and ulcer development. Cells known to contribute to cytokines and CXCL9 production in L. braziliensis-infected patients are represented below the corresponding soluble factor. CL, cutaneous leishmaniasis; ML, mucosal leishmaniasis; DL, disseminated leishmaniasis; SC, sub-clinical.