Table 3.
Reported Associations between Gene Expression and Copy Number for Chromosome 8q21.13 Genes
| Reviewed studies reporting gene overexpression associated with defined increased copy number |
Other genomic studies supporting amplification target gene status |
||||
|---|---|---|---|---|---|
| Gene symbol | Chromosome 8 location (Mb) | Tumor | Reference | Tumor | Reference |
| HEY1 | 80.838-80.842 | Breast (c) | Kao et al.40 | Breast (c) | Rodriguez et al.32 |
| Liver (t) | Jia et al.41 | ||||
| MRPS28 | 80.993-81.105 | Breast (t) | Chin et al.33 | Breast (c) | Rodriguez et al.32 |
| Breast (c) | Jönsson et al.45 | Breast (t) | André et al.50 | ||
| Liver (t) | Woo et al.38 | Breast (t) | Natrajan et al.51 | ||
| Breast (t) | Guedj et al.46 | Breast (t) | Staaf et al.54 | ||
| TPD52 | 81.109-81.155 | Prostate (t, c, x) | van Duin et al.37 | Breast (c, t) | Pollack et al.47 |
| Breast (c) | Jönsson et al.45 | Prostate (t) | Paris et al.49 | ||
| Breast (t) | Chin et al.33 | Breast (t) | Adélaïde et al.48 | ||
| Breast (c) | Rodriguez et al.32 | Breast (t) | André et al.50 | ||
| Breast (c) | Kao et al.40 | Breast (t) | Zhang et al.36 | ||
| Breast (t) | Guedj et al.46 | Hematopoietic (c) | Mattison et al.52 | ||
| Breast (t) | Natrajan et al.51 | ||||
| ZBTB10/RINZF | 81.561-81.597 | Prostate (t, c, x) | van Duin et al.37 | Breast (c) | Hyman et al.53 |
| Breast (c) | Kao et al.40 | Breast (c, t) | Pollack et al.47 | ||
| Ovarian (t) | Ramakrishna et al.35 | Breast (c) | Rodriguez et al.32 | ||
| Breast (t) | Zhang et al.36 | ||||
| Breast (t) | Staaf et al.54 | ||||
| FABP5 | 82.355-82.359 | Prostate (t) | Kim et al.34 | Prostate (t) | Paris et al.49 |
| Liver (t) | Jia et al.41 | ||||
| ZFAND1 | 82.776-82.796 | Breast (t) | Chin et al.33 | Breast (t) | André et al.50 |
| Ovarian (t) | Ramakrishna et al.35 | Breast (t) | Natrajan et al.51 | ||
| Breast (t) | Guedj et al.46 | Breast (t) | Staaf et al.54 | ||
| CHMP4C | 82.807-82.834 | Breast (t) | Chin et al.33 | Breast (t) | Natrajan et al.51 |
| Ovarian (t) | Ramakrishna et al.35 | ||||
| Breast (t) | Guedj et al.46 | ||||
| SNX16 | 82.874-82.916 | Ovarian (t) | Ramakrishna et al.35 | Breast (t) | André et al.50 |
| Breast (c) | Kao et al.40 | ||||
| Breast (t) | Natrajan et al.51 | ||||
Note: Genes contained within minimal regions of overlap (Fig. 3) are shown in bold. t = tissue; c = cell lines; x = xenografts.