Table 3.
Distribution of the genotypes, allele frequencies, and odd ratio of the β2 Arg16Gly polymorphism in total control, overweight, and obese subjects, separately in males and females.
| Group | No. | Genotype frequency* | Allele frequency** | |||||
|---|---|---|---|---|---|---|---|---|
| Arg∖Arg | Arg∖Gly | Gly∖Gly | χ 2/P | Arg | Gly | χ 2/P | ||
| Males | ||||||||
| Obese | 46 | 25 (54.3) | 9 (19.56) | 12 (26.1) | 3.82/0.43 | 59 | 33 | 5.02/0.08 |
| Overweight | 28 | 14 (50) | 7 (25) | 7 (25) | 35 | 21 | ||
| Control | 35 | 25 (71.4) | 5 (14.28) | 5 (14.28) | 55 | 15 | ||
| Females | ||||||||
| Obese | 100 | 51 (51) | 20 (20) | 29 (29) | 12.7/0.013 | 122 | 78 | 17.4/<0.0001 |
| Overweight | 40 | 20 (50) | 10 (25) | 10 (25) | 50 | 30 | ||
| Control | 80 | 56 (70) | 17 (21.25) | 7 (8.78) | 129 | 31 | ||
| Total group | ||||||||
| Obese | 146 | 76 (50.1) | 29 (19.9) | 41 (28.1) | 15.5/0.002 | 181 | 111 | 22.1/<0.0001 |
| Overweight | 68 | 34 (50) | 17 (25) | 17 (25) | 85 | 51 | ||
| Control | 115 | 81 (70.4) | 22 (19.1) | 12 (10.4) | 184 | 46 | ||
*For genotype frequency:
odds ratio (95% CI) control versus OW: 3.38 (1.456, 7.822);
odds ratio (95% CI) control versus Obese: 2.441 (0.667, 2.971);
P value for odds ratio in control versus overweight and control versus obese: P = 0.0001;
*statistically significant difference between the three groups (obese, overweight and normal);
**For allele frequency:
odds ratio (95% CI) control versus OW: 0.60 (0.46, 0.78) (P = 0.02);
odds ratio (95% CI) control versus obese: 0.70 (0.60, 0.810) (P = 0.001);
*allele frequency differs significantly in the different groups (P < 0.0001).
M: male; F: female; T: total; OW: overweight; CI: confidence interval.