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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Clin Cancer Res. 2012 Jun 18;18(16):4433–4440. doi: 10.1158/1078-0432.CCR-12-0761

Figure 2.

Figure 2

Influence of OATP1B1 variants on docetaxel transport in vitro. Transport of docetaxel (concentration, 0.1 μM; 60-min incubations) was evaluated in Flp-In T-Rex293 cells transfected with OATP1B1*1A (wildtype), OATP1B1*1B [c.388A>G (N130D); rs2306283], OATP1B1*5 [c.521T>C (V174A); rs4149056], or OATP1B1*15 (N130D, V174A). Data represent the mean of 6 observations, and are expressed as the average percent of uptake values in cells transfected with an empty vector (VC) in the absence or presence of 0.1% of polysorbate 80. Error bars represent the standard error. The star (*) denotes a significant difference from VC (P<0.05).