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. 2012 Oct;343(1):82–90. doi: 10.1124/jpet.112.192286

Fig. 4.

Fig. 4.

Modeling of spermine and ifenprodil binding to GluN1R and GluN2BR monomers. Modeling was done as described under Materials and Methods. A, spermine and ifenprodil binding to GluN1R and GluN2BR monomers is shown from two different angles, rotated by 90°. B, expanded spermine and ifenprodil binding sites on GluN1R and GluN2BR monomers. SPM, spermine; IFN, ifenprodil; NT, N terminus; CT, C terminus. Amino acid residues that influence spermine stimulation, ifenprodil inhibition, and both spermine stimulation and ifenprodil inhibition are depicted with a stick model in red, green, and blue, respectively.