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Modeling of spermine (A) and ifenprodil (B) binding sites on GluN1R and GluN2BR heterodimers. Modeling was done as described under Materials and Methods. NT, N terminus; CT, C terminus; R1 and R2, R1 and R2 lobes, respectively. The models show the approximate orientation of GluN1R and GluN2BR. The interaction energy of these complexes also is shown.
