Fig. 1.

Effects of pretreatment with JNJ16259685 and vehicle on the discriminative stimulus effects of cocaine (A) and the cocaine-like discriminative stimulus effects of methamphetamine (B) in monkeys trained to discriminate cocaine from saline. Top, percentage of responses on the cocaine-associated lever. Bottom, rate of responding. Data are mean ± S.E.M. Points above the Saline column show the effects of pretreatment with vehicle or JNJ16259685 before saline. #, p < 0.05, effects of cocaine or methamphetamine compared with saline. *, p < 0.05, effects of pretreatment with JNJ16259685 compared with its vehicle; Bonferroni t test.