Fig. 4.

Effects of pretreatment with JNJ16259685 and vehicle on reinstatement of drug seeking induced by cocaine priming and restoration of the cocaine-paired stimulus. A, cocaine priming dose-response curve after pretreatment with JNJ16259685 or vehicle. ▵ shows the baseline response rate under extinction conditions. ▴ shows the response rate after priming with a saline injection. B, within-session analyses showing the effects of pretreatment with JNJ16259685 or vehicle on the rate of responding during sequential components of reinstatement test sessions. *, p < 0.05, effects of pretreatment with JNJ16259685 compared with vehicle, Bonferroni t test.