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. 2012 Oct;343(1):53–61. doi: 10.1124/jpet.112.193433

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Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 1. — Disposition of norbuprenorphine and norbuprenorphine glucuronide. Concentrations of norbuprenorphine (A and B) and norbuprenorphine-3-glucuronide (C and D) were determined in brain homogenate (circles) and plasma (triangles) by LC/MS/MS. Results are shown for mdr1a(+/+) mice (open symbols) and mdr1a(−/−) mice (closed symbols). Measured concentrations are shown in A and C; norbuprenorphine and norbuprenorphine glucuronide brain/plasma ratios are shown in B and D. Each data point is the mean ± S.D. (n = 4). *, significantly different from mdr1a(+/+) controls (p < 0.05) by two-way repeated-measures analysis of variance.