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Proposed pathway for the inhibition of NE release from cardiac sympathetic neurons upon activation of mitochondrial ALDH2. This involves the pivotal phosphorylation/activation of mitochondrial ALDH2 by PKCε, which is translocated/activated when Gi/o-coupled receptors, such as A1, A3, and H3 receptors, are activated by adenosine and histamine released in ischemic conditions in close proximity to sympathetic nerve endings.
