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. 2012 Oct;32(10):474–484. doi: 10.1089/jir.2012.0031

FIG. 4.

FIG. 4.

Effect of MLCK inhibition on IL-1β-induced increase in mouse intestinal tight-junction (TJ) permeability in vivo. (A) IL-1β (5 μg/kg body weight) did not cause an increase in the mouse intestinal mucosal-to-serosal flux of dextran 10KD in MLCK−/− mice. *P<0.001 versus WT control. (B) Inhibition of MLCK with ML-7 (2 mg/kg) prevented the IL-1β-induced increase in the mouse mucosal-to-serosal flux of dextran 10KD. *P<0.001 versus control; **P<0.001 versus IL-1β treatment. (C) ML-7 (2 mg/kg) prevented the IL-1β-induced drop in mouse intestinal TER measured in Ussing chambers. *P<0.001 versus control; **P<0.001 versus IL-1β treatment.