Table II.
Genotype distribution of COX-2-1195G>A and -765G>C in case and control family groups.
| Locus genotype | Case family group (%)(n=296) | Control family group (%)(n=319) | OR (95% CI) |
|---|---|---|---|
| COX-2-1195 | |||
| G/G | 53 (17.9) | 80 (25.1) | 1.0 |
| G/A | 145 (49.0) | 166 (52.0) | 1.32 (0.86–2.01) |
| A/A | 98 (33.1) | 73 (22.9) | 2.03 (1.27–3.22)a |
| A carriers | 243 (82.1) | 239 (74.9) | 1.55 (1.02–2.28)a |
| G allele | 251 (42.4) | 326 (51.1) | 1.0 |
| A allele | 341 (57.6) | 312 (48.9) | 1.42 (1.09–1.81)a |
| COX-2-765 | |||
| G/G | 241 (81.4) | 275 (86.2) | 1.0 |
| G/C | 53 (17.9) | 43 (13.5) | 1.41 (0.91–2.20) |
| C/C | 2 (0.70) | 1 (0.30) | 2.28 (0.20–25.38) |
| C carriers | 55 (18.6) | 44 (13.8) | 1.44 (0.91–2.23) |
| G allele | 535 (90.4) | 593 (92.9) | 1.0 |
| C allele | 57 (9.60) | 45 (7.10) | 1.45 (0.92–2.25) |
a
Significant difference between study and control group (P<0.05). CI, confidence interval.