Various expression patterns of programmed death cell 4 (Pdcd4) in colorectal adenocarcinoma and normal cells. (A) Most normal colorectal epithelial cells revealed strong nuclear staining (upper left) compared with the staining in adenocarcinoma. (B-F) In carcinoma, various expression patterns were identified. (B) Moderate nuclear and weak cytoplasmic expression, (C) strong nuclear and weak cytoplasmic expression, (D) weak nuclear with moderate cytoplasmic expression, (E) extremely strong cytoplasmic expression, and (F) no expression in the either the nuclei or cytoplasms.