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TR3PV/PV mice spontaneously develop follicular thyroid carcinogenesis with pathological progression similar to human thyroid cancer. Panel A shows capsular invasion (arrows) in the thyroid, panel B shows a focus of vascular invasion (arrow), panel C shows an area of anaplasia (formation of spindle cells) in the thyroid, and panel D shows a low magnification of a metastatic lesion (arrow) in the lung.
