Table 4. Multivariate analysis of variance for shape changes in IRCSs.

Strain	Mandible
	df Num	df Den	Wilks	F	P
5A	14	49	0.292	6.23	<0.0001
6A	14	45	0.174	10.81	<0.0001
6C	14	51	0.208	10.3	<0.0001
49A	14	39	0.057	30.3	<0.0001
66H	14	42	0.052	37.74	<0.0001
103E	14	34	0.14	8.92	0.0006
119H	14	47	0.153	13.39	<0.0001
120C	14	45	0.02	89.49	<0.0001
122C	14	47	0.111	19.35	<0.0001
122D	14	39	0.23	6.19	<0.0001
122F	14	34	0.067	20.71	<0.0001
135B	14	45	0.159	12.05	<0.0001
135E	14	48	0.409	3.67	0.0008
137E	14	49	0.131	17.01	<0.0001
137F	14	42	0.232	6.83	<0.0001
137G	14	46	0.092	21.83	<0.0001
157F	14	49	0.242	8.05	<0.0001
157D	14	34	0.05	28.15	<0.0001

MANOVA tests for differences in shape by testing within group (i.e. an IRCS strain with C57BL/6). Differences in shape are calculated using a multivariate regression in which the independent variable is the strain, and the dependent variables are 14 first principal components of the tangent coordinates in the shape space. P values are corrected with a Bonferroni adjustment.