Table 2.
IgG antibody responses to infected erythrocytes surface antigens
| Parasitesa |
Seroprevalenceb(N = 67 pairs) |
IgG levelsc(N = 67 pairs) |
||||||
|---|---|---|---|---|---|---|---|---|
| SM | UM | Matched comparison | P | SM | UM | Matched comparison | P | |
| R29 |
64 (96) |
65 (97) |
5 (7) |
1.000 |
11.5 (8.7, 18.2) |
9.9 (6.6, 20.2) |
2.0 (−8.6, 9.1) |
0.088 |
| FCR3CSA |
8 (12) |
11 (16) |
15 (22) |
0.608 |
7.6 (6.6, 9.3) |
7.7 (6.7, 9.2) |
−0.3 (−2.3, 1.6) |
0.609 |
| E8BCD36 |
58 (87) |
62 (93) |
14 (21) |
0.414 |
6.7 (4.2, 11.3) |
6.9 (4.5, 10.7) |
−0.8 (−4.3, 4.5) |
0.636 |
| ITGICAM1 |
11 (16) |
15 (22) |
24 (36) |
0.300 |
1.1 (0.1, 2.1) |
1.3 (0.2, 2.5) |
−0.4 (−2.5, 1.6) |
0.345 |
| MOZ1 |
17 (25) |
18 (27) |
25 (37) |
0.666 |
28.0 (23.6, 31.8) |
26.9 (24.5, 33.9) |
0.01 (−5.5, 4.9) |
1.000 |
| MOZ2 |
40 (60) |
36 (54) |
34 (51) |
0.367 |
1.8 (0.8, 5.9) |
1.6 (0.8, 4.8) |
0.7 (−2.3, 3.8) |
0.334 |
| MOZ3 |
32 (48) |
30 (45) |
34 (51) |
0.611 |
2.6 (1.6, 4.1) |
2.4 (1.3, 4.9) |
0.2 (−2.3, 2.3) |
0.650 |
| MOZ4 |
47 (70) |
44 (66) |
27 (40) |
0.704 |
5.3 (−1.4, 24.9) |
3.3 (−1.4, 13.1) |
2.8 (−11.9, 19.1) |
0.329 |
| MOZ5 |
51 (76) |
56 (83) |
24 (36) |
0.293 |
88.0 (53.1, 115.4) |
83.4 (62.3, 129.9) |
−7.4 (−45.7, 35.6) |
0.727 |
| PLC1 |
0 (0) |
3 (4) |
3 (4) |
0.255 |
58.3 (53.2, 64.8) |
60.7 (51.9, 67.5) |
−1.1 (−8.7, 7.3) |
0.547 |
| PLC2 | 0 (0) | 3 (4) | 3 (4) | 0.255 | 19.8 (12.3, 24.2) | 18.6 (10.1, 24.5) | −0.7 (−8.2, 8.9) | 0.907 |
a MOZ, isolates from Mozambican children; PLC, placental isolates from Mozambican women.
b Presented as the number (%) of responders. Matched comparison reports the number (%) of divergent pairs. P-values calculated using McNemar’s test. Thresholds for seroprevalence (MFI): R29 = 5.1, FCR3CSA = 10.1, E8BCD36 = 2.6, ITGICAM = 2.7, MOZ1 = 31.7, MOZ2 = 1.4, MOZ3 = 2.9, MOZ4 = 0.4, MOZ5 = 52.6, PLC1 = 107.6, PLC2 = 42.9.
c Presented as medians (inter-quartile range) of MFI values. Matched comparison reports the median difference (inter-quartile range) of IgG levels between SM and UM. P-values calculated using Sign test.
All comparisons were corrected by the Monte Carlo permutation test (1000 random permutations).