Table 2.
Growth outcomes and human milk fortification for all subjects and by human milk intake
| |
|
Group by proportion of enteral intake as human milk |
p value |
||||
|---|---|---|---|---|---|---|---|
| All Subjects | <25% | 25-50% | 50-75% | >75% | All groups | >75% vs. <75% | |
|
Discharge weight, g, median (IQR) |
2782 (2460, 3215) |
3005 (2470, 3260) |
2765 (2500, 3690) |
2980 (2695, 3280) |
2685 (2335, 3035) |
0.008* |
0.0006 |
|
Discharge weight z- score, median (IQR) |
−0.94 (−1.43, -0.19) |
−0.72 (−1.43, -0.19) |
−0.69 (−1.36, -0.05) |
−0.95 (−1.28, 0.12) |
−1.07 (−1.52, -0.29) |
0.36* |
0.09 |
|
SGA at discharge n (%) |
58 (34) |
7 (41) |
8 (27) |
9 (25) |
34 (39) |
0.36* |
0.18 |
|
Protein fortification, highest level |
|
|
|
|
|
|
|
|
n (%) |
|
|
|
|
|
|
|
|
2.0-2.3 g/dl |
34 (20) |
6 (35) |
8 (27) |
6 (17) |
14 (16) |
0.04† |
0.18 |
|
2.4-2.65 g/dl |
84 (49) |
6 (35) |
14 (46) |
16 (44) |
48 (55) |
|
|
|
2.5-2.7 g/dl |
53 (31) |
5 (29) |
8 (27) |
14 (39) |
26 (30) |
|
|
| Change in weight z-score, birth to discharge, median (IQR) | −0.51‡ (−0.89, -0.03) | −0.1 (−0.61, 0.16) | −0.30 (−0.85, 0) | −0.32 (−0.73, 0.15) | −0.60 (−0.99, -0.15) | 0.17* | 0.03 |
*ANOVA or Chi square across all groups.
†Chi square across all fortification levels and all human milk intake groups.
‡ p < 0.0001 – t-test of change in weight z score = 0, infants experienced significant negative change in weight z-score from birth to discharge.