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. 2012 Oct 4;8(10):e1002710. doi: 10.1371/journal.pcbi.1002710

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) C_α RMSD of the ECD (upper panel), whole protein (middle panel), and TMD (lower panel) for the WT (dark red), F(14′)A (dark blue), WT+ethanol (light red), and F(14′)A+ethanol (light blue) simulations relative to the GLIC crystal structure (PDB ID 3EAM). Right hand panel shows the GLIC structure colored by chain. (B) Average RMSD per residue over the four 1-µs simulations, colored as in (A). ECD includes residues 5 to 195, TMD residues 196 to 315. Box indicates high-RMSD residues 222–245, with residue 238 labeled according to M2 prime notation (14′).