Table 2. Inter-subunit cavity properties.

		1	2	3	4	5	Average
Volume a	WT	138±95	62±52	181±80	64±64	36±38	96±33
	F(14′)A	178±159	496±134	136±86	23±32	580±154	283±45
	WT+ethanol	212±122	125±58	88±55	181±46	194±79	160±35
	F(14′)A+ethanol	180±60	559±112	293±77	73±78	267±150	274±45
Water b	WT	2.0±1.3	0.7±0.7	1.2±0.9	0.7±0.9	0.6±0.8	1.0±0.4
	F(14′)A	2.6±2.8	7.8±1.9	1.5±1.1	1.5±0.9	8.7±2.4	4.4±0.8
	WT+ethanol	2.1±1.5	0.3±0.5	0.8±1.0	0.3±0.7	1.1±0.9	0.9±0.4
	F(14′)A+ethanol	1.9±1.0	4.5±1.9	1.3±0.9	0.8±0.5	1.5±1.3	2.0±0.5
Ethanol b	WT+ethanol	0.3±0.5	0.2±0.4	0.0±0.0	0.8±0.4	0.4±0.5	0.3±0.2
	F(14′)A+ethanol	0.6±0.5	1.6±0.7	1.2±0.4	0.0±0.0	0.7±0.7	0.8±0.2

Average volume and number of solvent molecules in each inter-subunit cavity, as well as cavity averages, computed over the second half (500 ns) of each simulation. Errors are standard deviations.

^aVolume computed using mdpocket module of the Fpocket package, expressed in ų.

^bAverage number of molecules computed.