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. 2012 Oct 4;8(10):e1002696. doi: 10.1371/journal.pcbi.1002696

Figure 1. Regulatory functions of ABPs.

Figure 1

Auto-inhibited WASP is activated by binding Cdc42, and can then work with the Arp2/3 complex to nucleate new actin filaments (direction indicated by a dashed block arrow). By forming 1∶1 complexes with G-actin, ABPs like profilin, ciboulot, Tβ4, twinfilin, and DBP prevent spontaneous nucleation. With these 1∶1 complexes, some (profilin and ciboulot) still allow addition at the barbed end of actin filaments, and others (Tβ4, twinfilin, and DBP) just sequester G-actin. Gelsolin servers and then caps the barbed end of actin filaments.