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. 2012 Oct 4;8(10):e1002713. doi: 10.1371/journal.pcbi.1002713

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© 2012 Romero, Arnold

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Note diagonal lines represent . (A) The random field's expected fraction of functional sequences shows quantitative agreement with experimental results ( with ). Error bars represent the binomial 95% confidence intervals calculated using the Clopper-Pearson method [51]. (B) The expected additivity agrees well with experimentally determined values ( with ). While the small data set limits the statistical significance of this correlation, all s are large and within the ranges that are observed experimentally.

Inline graphic — Note diagonal lines represent . (A) The random field's expected fraction of functional sequences shows quantitative agreement with experimental results ( with ). Error bars represent the binomial 95% confidence intervals calculated using the Clopper-Pearson method [51]. (B) The expected additivity agrees well with experimentally determined values ( with ). While the small data set limits the statistical significance of this correlation, all s are large and within the ranges that are observed experimentally.