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. 2012 Oct 4;8(10):e1002958. doi: 10.1371/journal.ppat.1002958

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© 2012 Le et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic diagram of TEP1*R1, TEP1*S1 and the chimera TEP1*R1-sTED2, and location of thioester Gln 862 (star) and MG3 Asn 312. (B–C) Rate of TEP1_cut precipitation. (B) TEP1*S1_cut (open squares) and TEP1*R1_cut-sTED2 (open diamonds) precipitate within 1.5 days, while (C) TEP1*R1_cut (squares) and TEP1*R1_cut-N312D (diamonds) precipitate over several weeks. (D) Rate of thioester hydrolysis for TEP1*S1 (open squares) by quantitative mass spectrometry. (E) Measured half-life for thioester hydrolysis of TEP1 proteins.