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. 2012 Oct 4;7(10):e46679. doi: 10.1371/journal.pone.0046679

Figure 1. The workflow of standard LSC and the outline of error correction based on HC transformation.

Figure 1

(a) LSC consists of five steps: HC transformation of SRs and LRs, SR quality control, SR-LR alignment, error correction and decompression transformation. LSC outputs the sequence from the left-most SR-covered point to the right-most SR-covered one. (b) In the SR-LR layout, correction points consist of four types: HC points, point mismatches, deletions and insertions. Each correction point is treated independently and replaced by the consensus sequence from SRs for the first three types. Insertion sequence at position i is treated as a whole at the gap between two positions i and i+1 of the compressed LRs. A consensus sequence of this gap is inserted to the final output at the corresponding position.