Table 1. Total and non-HDL, VLDL, IDL, LDL, and HDL plasma cholesterol (mg/dl) at day 14 after saline injection or gene transfer with 5×1010 particles of Adnull (Controls), after gene transfer with 5×1010 particles of AdLDLr, and after gene transfer with 5×1010 particles of AdA-I in female C57BL/6 LDLr−/− mice fed a diet containing 0.2% cholesterol, 10% coconut oil.
Controls | AdLDLr | AdA-I | |
Total | 353±10 | 81.7±4.5** | 390±16* |
Non-HDL | 302±9 | 42.0±3.4** | 298±11 |
VLDL | 65.4±5.9 | 9.62±1.25** | 69.2±3.5 |
IDL | 138±4 | 13.9±1.1** | 133±5 |
LDL | 98.8±3.5 | 18.5±1.7** | 96.0±2.6 |
HDL | 51.0±1.9 | 39.7±1.6* | 91.3±5.1** |
Data are expressed as means ± SEM (n = 10 for each condition). Lipoproteins were isolated by ultracentrifugation.
:p<0.05,
:p<0.01 for comparison versus Controls.