Table 2. Morphometric analysis of the myocardium in C57BL/6 LDLr−/− mice 6 weeks after saline injection or gene transfer with Adnull (controls), gene transfer with AdLDLr, and gene transfer with AdA-I.
Controls n = 13 | AdLDLr n = 14 | AdA-I n = 10 | |
Cardiomyocyte cross-sectional area (µm2) | 219±18 | 184±10 | 188±8 |
Cardiomyocyte density (number/mm2) | 4490±300 | 5410±230* | 4900±180 |
Capillary density (number/mm2) | 5820±360 | 7460±330** | 7190±410* |
Capillary density/cardiomyocyte density | 1.29±0.05 | 1.38±0.04 | 1.46±0.05* |
Relative vascularity (µm−2) | 0.00639±0.00045 | 0.00782±0.00043* | 0.00794±0.00046* |
Data are expressed as means ± SEM.
:p<0.05,
:p<0.01 for comparison versus Controls.