Table 4. Functional enrichment analysis of top genes associated with pancreatic cancer (P<0.01 from KLM)a.
| Cluster (Enrichment scoreb) | Biological process | Database code | No. of genes | P valuec |
| 1 (6.61) | GPCR, rhodopsin-like superfamily | IPR017452 | 26 | 1.61×10−11 |
| 7TM GPCR, rhodopsin-like | IPR000276 | 26 | 1.66×10−11 | |
| Olfactory receptor | IPR000725 | 18 | 5.11×10−9 | |
| Sensory perception of smell | GO:0007608 | 18 | 1.30×10−7 | |
| G-protein coupled receptor protein signaling pathway | GO:0007186 | 29 | 1.53×10−7 | |
| Sensory perception of chemical stimulus | GO:0007606 | 18 | 5.60×10−7 | |
| Cell surface receptor linked signal transduction | GO:0007166 | 36 | 2.58×10−6 | |
| Sensory perception | GO:0007600 | 22 | 4.01×10−6 | |
| Cognition | GO:0050890 | 23 | 6.91×10−6 | |
| Neurological system process | GO:0050877 | 25 | 6.71×10−5 | |
| Olfactory transduction | hsa04740 | 18 | 2.38×10−3 | |
| 2 (1.97) | Homeostatic process | GO:0042592 | 18 | 1.97×10−4 |
| Chemical homeostasis | GO:0048878 | 14 | 4.03×10−4 | |
| Cellular cation homeostasis | GO:0030003 | 9 | 1.45×10−3 | |
| Activation of phospholipase C activity | GO:0007202 | 5 | 2.25×10−3 | |
| Positive regulation of phospholipase C activity | GO:0010863 | 5 | 2.25×10−3 | |
| Positive regulation of phospholipase activity | GO:0010518 | 5 | 2.80×10−3 | |
| Cation homeostasis | GO:0055080 | 9 | 3.04×10−3 | |
| Regulation of phospholipase activity | GO:0010517 | 5 | 3.11×10−3 | |
| Positive regulation of lipase activity | GO:0060193 | 5 | 3.79×10−3 | |
| Second-messenger-mediated signaling | GO:0019932 | 8 | 3.91×10−3 | |
| Cellular ion homeostasis | GO:0006873 | 10 | 4.59×10−3 | |
| Cellular chemical homeostasis | GO:0055082 | 10 | 5.09×10−3 | |
| Cellular homeostasis | GO:0019725 | 11 | 6.33×10−3 | |
| Regulation of lipase activity | GO:0060191 | 5 | 6.42×10−3 | |
| Ion homeostasis | GO:0050801 | 10 | 8.10×10−3 | |
| Activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | GO:0007200 | 4 | 9.77×10−3 |
a
DAVID analysis was based on GO, InterPro, and KEGG database.
b
The group enrichment score is the geometric mean (in -log scale) of member gene sets’ P values in a corresponding annotation cluster.
c
The P value is based on a modified Fisher’s exact test in the DAVID system, referring to one-tail Fisher’s exact probability value used for gene-enrichment analysis.