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The amino acids that form the hydrogen bond network with steroidal agonists are highlighted in ball and stick style. AF-2 (helix 12) is colored in dark blue, helix 5 in green, helix 3 in light blue, and the β-sheet in lilac. The buried hydrophobic pocket additionally occupied by AB110873 is formed by amino acids from helices 3 (Val780) and 5 (Leu809, Ala813), and from the β-sheet (Val750).
