Table 2.

In- and exclusion criteria for the GIPS-III trial. MI: myocardial infarction; ECG: electrocardiogram; PCI: percutaneous coronary intervention; MRI: magnetic resonance imaging

Inclusion criteria	Exclusion criteria
• The diagnosis acute MI defined by chest pain suggestive for myocardial ischemia for at least 30 min, the time from onset of the symptoms less than 12 h before hospital admission, and an ECG recording with ST- segment elevation of more than 0.1 mV in 2 or more leads	• Prior MI
	• Diabetes
	• Creatinin >177 μmol/L measured pre-PCI
	• Need for coronary artery bypass grafting
	• Rescue PCI after thrombolytic therapy
• Successful primary PCI <12 h from onset of symptoms	• When subjects develop a condition which, in the investigator’s judgment, precludes study therapy
• Verbal followed by written informed consent	• Inability to provide informed consent
• At least one stent sized ≥3.0 mm	• Younger than 18 years
• Eligible for cardiac MRI-scan:	• Contra-indication to metformin
- Body Mass Index <40 kg/m2	• an estimated life-expectancy of less than 6 months
- no ferromagnetic metal objects in the body
- no claustrophobia