Table 2.
Serum Lipid Profile of Hyperlipidemic Mice
| Group | TC (mmol/L) | TG (mmol/L) | LDL-c (mmol/L) | HDL-c (mmol/L) | AI |
|---|---|---|---|---|---|
| Normal control | 2.11±0.15 | 0.69±0.23 | 0.23±0.04 | 1.46±0.22 | 0.47±0.19 |
| Model control | 21.6±6.37a | 1.25±0.37b | 19.35±5.29a | 1.16±0.19b | 17.9±6.86a |
| rhHDL (1.25 mg/kg) | 7.34±1.01c | 0.78±0.19d | 2.03±0.33c | 2.24±0.25c | 2.27±0.46c |
| rhHDL (2.5 mg/kg) | 5.91±0.53c | 0.72±0.21d | 1.77±0.29c | 2.42±0.30c | 1.44±0.34c |
| Native HDL (2.0 mg/kg) | 5.06±0.48c | 0.75±0.32d | 1.46±0.22c | 2.43±0.21c | 1.09±0.25c |
Normal control (NC) and model control (MC) groups were treated with vehicle; low-dose (LD) and high-dose (HD) groups were treated with rhHDL 2 mg/kg and 4 mg/kg, respectively; the positive control group (PC) was treated with native HDL 4 mg/kg once daily.
Data are mean±standard error of the means (n=10).
aP<0.001 versus normal control.
bP<0.05 versus normal control.
cP<0.001 versus model control.
dP<0.05 versus model control.
TC, total cholesterol; TG, triglyceride; LDL-c, low-density lipoprotein cholesterol; HDL-c, high-density lipoprotein cholesterol; AI, atherogenic index.