Table 2.
KCTD8 locus in female adolescents (Saguenay Youth Study; n = 290) and age-adjusted brain volume (ccm, mean [standard error])
| SNP | Allele 1 | Allele 2 | Frequency 1 | MAF | P value | 1-1 | 1-2 | 2-2 |
| rs716890 (5) | G | T | 0.24 | 0.24 | 5.4 × 10−09 | 1178 (19) | 1194 (8) | 1256 (6) |
| rs7686284 (1) | A | G | 0.29 | 0.29 | 8.2 × 10−09 | 1188 (17) | 1198 (7) | 1260 (7) |
| rs1027201 (3) | C | T | 0.71 | 0.29 | 8.2 × 10−09 | 1260 (7) | 1198 (7) | 1188 (17) |
| rs6811002 (6) | C | T | 0.27 | 0.27 | 9.3 × 10−09 | 1185 (17) | 1196 (8) | 1256 (6) |
| rs7689563 (10) | A | G | 0.25 | 0.25 | 1.1 × 10−08 | 1178 (19) | 1195 (8) | 1256 (6) |
| rs17641380 (2) | C | T | 0.26 | 0.26 | 1.8 × 10−08 | 1181 (20) | 1197 (7) | 1257 (6) |
| rs7682929 (8) | A | C | 0.20 | 0.20 | 2.1 × 10−08 | 1180 (29) | 191 (8) | 1250 (6) |
| rs6447330 (11) | A | G | 0.75 | 0.25 | 3.9 × 10−08 | 1256 (6) | 1196 (8) | 1178 (19) |
| rs17599605 (9) | C | T | 0.73 | 0.27 | 4.7 × 10−07 | 1254 (7) | 1201 (8) | 1185 (18) |
| rs10007704 (7) | C | T | 0.44 | 0.44 | 1.2 × 10−05 | 1196 (12) | 1222 (7) | 1258 (9) |
| rs4695701 (4) | C | T | 0.50 | 0.50 | 2.0 × 10−05 | 1199 (10) | 1223 (7) | 1268 (10) |
Note: 1-1, 1-2, and 2-2 indicate genotypes relative to allele 1 and allele 2. Note that Allele 1 is the minor allele in all but 3 cases (highlighted in gray). Carriers of a minor allele have smaller brain volume than major allele homozygotes. Numbers in brackets following the SNP identifiers correspond to those in Figure 1. MAF, minor allele frequency.