Figure S6.

RSD-6 Is Required in Germ Cells for Environmental dsRNA, Related to Figure 5C

Bacteria expressing dsRNA targeting pop-1 or par-6, which are expressed in the maternal germline to promote embryogenesis (Lin et al., 1995; Watts et al., 1996), cause highly penetrant embryonic lethality when fed to wild-type but not to rsd-6 mutant hermaphrodites. Single copy transgenes that express rsd-6 ubiquitously (Pdpy-30::rsd-6) or in the germline (Ppgl-3::rsd-6) both rescue the responses of an rsd-6 mutation to pop-1 or par-6 dsRNA.