FIG. 2.

Growth inhibition activity of antisense peptide–PNA conjugates and mismatch controls. Dose dependent effect of anti-acpP and ftsZ peptide–PNA conjugates and their mismatch controls on the growth of PA01. Bacteria were grown in the absence of PNA (closed square) and different doses of peptide–PNA conjugates (open square, open triangle, inverted open triangle, open rhombus, and open circle). PNA 3993, PNA 3985, PNA 4070, and PNA 4072 are the mismatch controls of PNA 3969, PNA 3984, PNA 4071, and PNA 4073, respectively. PNA 3969 and PNA 3984 target the acpP mRNA sequence and PNA 4071 and PNA 4073 target ftsZ, as indicated.