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. Author manuscript; available in PMC: 2012 Oct 5.
Published in final edited form as: Cancer Res. 2011 May 6;71(13):4675–4685. doi: 10.1158/0008-5472.CAN-10-4558

Figure 1. Perinatal loss of Nf1 mice causes two phases of mortality and late neurofibroma formation.

Figure 1

(A) Kaplan-Meyer survival curve (p < 0.0001). (B) Gross dissection of cervical spinal cord with DRG-associated small GEM Grade I neurofibromas at each dorsal root in a PlpCre+;Nf1fl/fl animal at 18 months of age. Ruler shows 1mm markings. (C) Tissue sections of GEM Grade I neurofibroma in PlpCre+;Nf1fl/fl animal after perinatal tamoxifen. Upper panels are magnified 10×; lower panels 25×. Red arrows highlight mast cells.