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. Author manuscript; available in PMC: 2012 Oct 5.
Published in final edited form as: Cancer Res. 2011 May 6;71(13):4675–4685. doi: 10.1158/0008-5472.CAN-10-4558

Figure 5. Disrupted Remak bundles in PlpCre;Nf1fl/fl nerves.

Figure 5

Electron micrographs of the saphenous nerves of 12 month old (A) PlpCre+;WT control, (B) P1-3 tamoxifen-injected PlpCre+;Nf1fl/fl, and (C) adult tamoxifen-injected PlpCre+;Nf1fl/fl animals. Large Arrows in B & C highlight Remak bundle disruption; arrowheads highlight myelin sheaths in B & C. 4,000× = upper panels. 40,000× = lower panels. Schwann cell cytoplasmic processes are identified by their continuous basal lamina (small arrows lower panels).