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Impairment of PI3Kinase/Akt signaling in human advanced HF. (A) Reduced activation indicated by decreased phosphorylation status of Akt and FOXO in samples from patients with advanced HF compared to control subjects (three representative samples per group). (B) Decreased myocardial phosphorylation levels of Akt and FOXO in patients with advanced HF compared to controls (*p<0.05, n=6–8 samples per group).
