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Mechanical unloading of the failing myocardium increased cardiac PI3K/Akt/Foxo signaling. (A) Increased myocardial activation of Akt and Foxo following LVAD placement. (B) Quantitative analysis of Akt and Foxo activation. (empty bars – pre-LVAD; filled bars – post-LVAD; n=6 individual patients before and after LVAD implantation; *p<0.05 vs. pre-LVAD).
