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The box III–box I palindrome is conserved in evolution. Origins of DNA replication were identified by sequence analysis of completely sequenced alpha herpes virus genomes identified by the GenBank entry numbers. Origins of DNA replication from VZV, human herpes virus 6, and human herpes virus 7 were not included in this comparison. Recognition sequences for OBP are highlighted in bold. Nucleotides deviating from the canonical recognition sequence GTTCGCAC are underlined.
