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. 2012 Aug 17;287(41):34069–34077. doi: 10.1074/jbc.M112.385518

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — A model for the KIBRA-Aurora-Lats2 axis in mitosis. In mitosis, KIBRA, as an Aurora-A interacting partner, regulates Aurora-A kinase activity. Meanwhile, activated Aurora-A phosphorylates KIBRA Ser⁵³⁹, which in turn is dephosphorylated by PP1 during mitotic exit. KIBRA contributes to the phosphorylation of Lats2 on Ser⁸³ by Aurora-A kinase. Lats2 reduces the phosphorylation of KIBRA Ser⁵³⁹, probably through regulating PP1 activity. Arrows and bars indicate positive and negative regulations, respectively.