FIGURE 1.
The ability of eight d-LAK peptides to inhibit the growth of M. tuberculosis H37Ra is shown and compared with a positive growth control (1 × 106 cfu/ml) and a 1% growth control (1 × 104 cfu/ml). When histidine-free peptides are compared (A), a reduction of antibacterial activity is observed when proline is incorporated. For histidine-containing peptides (B), incorporation of proline increases antibacterial activity. Altering the angle subtended by the lysine residues to either 80° or 160° diminishes peptide potency.