TABLE 1.
Comparison of physical features of peptides used in this study
Hydrophobicity (H) and mean hydrophobic moment (μH) are shown according to the combined consensus scale or Eisenberg scale and were calculated using the HydroMCalc Java applet made available by Alex Tossi. All peptides contain eight lysine residues and are amidated at the C terminus, which confers a nominal charge of +9 at neutral pH. d-Amino acid residues are shown in italics. Significant changes to the sequences are highlighted: histidine, phenylalanine, and proline residues are highlighted in bold with proline also underlined.
| Peptide | Sequence | Ha | Hb | μHa,c |
|---|---|---|---|---|
| d-LAK120 | KKLALLALKKWLLALKKLALLALKK-NH2 | 1.26 | −0.05 | 1.28 |
| d-LAK120-P13 | KKLALLALKKWLPALKKLALLALKK-NH2 | 0.87 | −0.07 | 1.66 |
| d-LAK120-A | KKLALALAKKWLALAKKLALALAKK-NH2 | −0.02 | −0.08 | 2.28 |
| d-LAK120-AP13 | KKLALALAKKWLPLAKKLALALAKK-NH2 | 0.00 | −0.10 | 2.25 |
| d-LAK120-H | KKLALHALKKWLHALKKLAHLALKK-NH2 | −0.35 | −0.16 | 2.80 |
| d-LAK120-HP13 | KKALAHALKKWLPALKKLAHALAKK-NH2 | −1.07 | −0.17 | 3.81 |
| d-LAK80-HP13 | KKALAKALKHWLPALHKLAKALAKK-NH2 | −1.07 | −0.17 | 4.02 |
| d-LAK160-HP13 | KKALKHALAKWLPALKALAHKLAKK-NH2 | −1.07 | −0.17 | 3.40 |
| LAK80 | KKLAKALKLLALLWLKLAKALKKA-NH2 | 0.46 | −0.09 | 3.73 |
| LAK80-P7 | KKLAKAPKLLALLWLKLAKALKKA-NH2 | 0.05 | −0.11 | 3.46 |
| LAK80-P10 | KKLAKALKLPALLWLKLAKALKKA-NH2 | 0.05 | −0.11 | 3.33 |
| LAK80-P12 | KKLAKALKLLAPLWLKLAKALKKA-NH2 | 0.05 | −0.11 | 4.14 |
| LAK120 | KKLALALKKLALLWKKLALALKKA-NH2 | 0.46 | −0.09 | 3.02 |
| LAK120-P7 | KKLALAPKKLALLWKKLALALKKA-NH2 | 0.05 | −0.11 | 2.76 |
| LAK120-P10 | KKLALALKKPALLWKKLALALKKA-NH2 | 0.05 | −0.11 | 2.62 |
| LAK120-P12 | KKLALALKKLAPLWKKLALALKKA-NH2 | 0.05 | −0.11 | 3.43 |
| LAK160 | KKLKLALAKLALLWKALALKLKKA-NH2 | 0.46 | −0.09 | 2.59 |
| LAK160-P7 | KKLKLAPAKLALLWKALALKLKKA-NH2 | 0.05 | −0.11 | 2.34 |
| LAK160-P10 | KKLKLALAKPALLWKALALKLKKA-NH2 | 0.05 | −0.11 | 2.18 |
| LAK160-P12 | KKLKLALAKLAPLWKALALKLKKA-NH2 | 0.05 | −0.11 | 3.00 |
| LAK80-F1 | FKKLAKALKLLALLALKLAKALKKA-NH2 | 0.41 | −0.06 | 3.36 |
| LAK80-F2 | FFKKLAKALKLLALLALKLAKALKKA-NH2 | 0.78 | −0.04 | 3.55 |
| LAK80-F2-P9 | FFKKLAKAPKLLALLALKLAKALKKA-NH2 | 0.40 | −0.06 | 3.30 |
a Combined consensus scale.
b Eisenberg scale.
c Mean hydrophobic moment assuming formation of ideal α-helix.