TABLE 2.

Comparison of MIC₅₀, EC₅₀, and HC₅₀ values (μm) for eight designed linear cationic peptides comprising all d-amino acids

Results are an average of two or more independently repeated experiments. HC₅₀ values greater than 10 times the EC₅₀ for antiplasmodial activity for either strain are highlighted in bold. ND, not determined.

Peptide	MIC50			EC50				Hemolysis, HC50
	E. coli NCTC 9001	P. aeruginosa PAO1	E. coli TOP10	P. falciparum 3D7	P. falciparum C10	A549	RAW264.7
d-LAK120	1.48 ± 0.53	2.71 ± 1.07	0.62 ± 0.15	1.95 ± 0.08	ND	ND	ND	4.06 ± 1.30
d-LAK120-P13	1.54 ± 0.97	1.42 ± 0.41	0.58 ± 0.18	0.88 ± 0.08	2.18 ± 0.41	2.44 ± 0.43	3.80 ± 0.34	11.66 ± 0.03
d-LAK120-A	1.23 ± 0.47	1.83 ± 0.63	0.38 ± 0.21	1.45 ± 0.12	2.13 ± 0.14	5.23 ± 0.35	7.31 ± 2.13	17.42 ± 2.17
d-LAK120-AP13	1.08 ± 0.62	1.22 ± 0.19	0.29 ± 0.09	0.88 ± 0.06	2.36 ± 0.10	3.11 ± 0.57	3.42 ± 0.16	58.61 ± 10.41
d-LAK120-H	1.54 ± 0.01	1.35 ± 0.07	0.40 ± 0.01	1.26 ± 0.14	4.43 ± 0.33	4.54 ± 0.30	5.21 ± 0.57	20.29 ± 2.42
d-LAK120-HP13	ND	ND	ND	ND	2.88 ± 0.25	2.21 ± 0.63	2.33 ± 0.30	79.61 ± 2.80
d-LAK80-HP13	ND	ND	ND	ND	0.96 ± 0.07	6.50 ± 0.37	7.08 ± 1.42	8.61 ± 0.35
d-LAK160-HP13	ND	ND	ND	ND	3.94 ± 0.33	7.58 ± 0.42	3.95 ± 0.40	185.0 ± 18.65