TABLE 3.

Comparison of MIC₅₀ values (μm) for 12 designed linear cationic peptides

Results are an average of two or more independently repeated experiments. ND, not determined. Proline-free template peptides are indicated in bold.

Peptide	E. coli NCTC 9001	P. aeruginosa PAO1	E. coli TOP10
LAK80	13.05 ± 0.13	ND	ND
LAK80-P7	2.97 ± 0.15	2.13 ± 0.77	1.26 ± 0.49
LAK80-P10	1.62 ± 0.17	1.18 ± 0.53	0.82 ± 0.03
LAK80-P12	1.80 ± 0.27	0.86 ± 0.09	0.80 ± 0.01
LAK120	2.95 ± 0.06	4.20 ± 0.92	1.47 ± 0.64
LAK120-P7	0.80 ± 0.03	4.45 ± 0.19	0.45 ± 0.10
LAK120-P10	0.78 ± 0.01	9.16 ± 1.43	0.47 ± 0.15
LAK120-P12	0.97 ± 0.06	2.14 ± 0.53	0.68 ± 0.14
LAK160	1.11 ± 0.48	2.23 ± 0.41	0.73 ± 0.40
LAK160-P7	0.79 ± 0.41	2.98 ± 0.21	0.46 ± 0.11
LAK160-P10	2.22 ± 0.63	4.14 ± 0.23	0.45 ± 0.24
LAK160-P12	0.48 ± 0.20	1.69 ± 0.09	0.38 ± 0.08